Molecular self-assembly has been exploited in Nature to develop the complex higher macromolecular structures of both the genome and proteome. Our work in PBNG focus on understanding the fundamentals behind self-assembly of protein structures and learning lessons from those biomacromolecules for the de novo design of ultra-short constrained peptides that self-assemble into bio-inspired β-sheet nanofibers.
We have manipulated those peptide-based nanostructures for the innovation of novel stable, responsive and functional bionanomaterials with potential various pharmaceutical, biomedical and biotechnological applications. Fabrication of soft biomaterials such as hydrogels, emulgels, nanofibrillised microcapsules as well as nanoparticles was achieved through the bottom-up peptide molecular engineering. Recently, we have started exploring the interfacial activity of those self-assembled structures with the potential applications as emulsifiers and as stabilising agents in biopharmaceuticals. Another recent area of interest is using nanofibrillised peptide microcapsules for encapsulation of stem cells as safe vehicles for cell therapy application.
- Drug functionalised peptide nanofibers for cancer therapeutics
- Self-assembling peptide nanofibers as interfacial stabilisation systems for emulsion formulations
- Nano-fibrillised peptide microcapsules for stem cells encapsulation
- Peptide nanoparticles for targeted drug delivery
- Self-assembling peptide nanofibers as protein aggregation suppressors in Biopharmaceuticals
- Microfluidics for the fabrication of peptide emulgels